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KMID : 1145120170150040501
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Asian Journal of Beauty and Cosmetology
2017 Volume.15 No. 4 p.501 ~ p.511
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Physiological Activities of Parsley Extracts as an Ingredient of Functional Cosmetics
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Choi Jung-Eun
Moon Ji-Sun
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Abstract
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Purpose: This study attempted to examine the active effects of 70% ethanol extracts of parsley (Petroselinum crispum) and verify its usefulness as an ingredient of functional cosmetics.
Methods: Parsley was extracted using 70% ethanol and, to verify its anti-inflammatory, anti-aging, and skin-brightening effects, its total polyphenol content, and total flavonoid content, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, as well as its ability to synthesize nitric oxide (NO), suppress cyclooxygenase 2 (COX2) and inhibit microphthalmia-associated transcription factor (MITF) and tyrosinase were assessed and phospho-extracellular signal?regulated kinase (p-ERK), phospho-c-Jun N-terminal kinase (p-JNK).
Results: Total polyphenol and flavonoid contents and DPPH radical scavenging activity of parsley extracts were verified. From results of cytotoxicity test on parsley extracts in RAW 264.7, B16F10, and human dermal fibroblast cells, following experiments were conducted at concentrations which cytotoxicity was not observed. The result showed good MITF inhibition, but poor tyrosinase inhibition. In addition, NO and COX2 were inhibited and phosphorylation of JNK was suppressed.
Conclusion: Parsley extracts have remarkable anti-oxidant effects and are valuable as a cosmetics ingredient with anti-inflammatory, skin-brightening, and anti-aging effects.
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KEYWORD
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Parsley, Anti-oxidant, Melanin, Anti-inflammation, Anti-aging
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